ICI 204448

Description

CAS Number: 121264-04-8

ICI 204448 is a potent, selective, and peripherally restricted kappa-opioid receptor (KOR) agonist. Characterized by negligible blood-brain barrier penetration, it is widely utilized as a pharmacological tool to distinguish peripheral from central opioid receptor-mediated pathways.

Pharmacological Profile:

• Target: Kappa-opioid receptor (KOR) agonist
• Selectivity: High selectivity for KOR over mu- (MOR) and delta- (DOR) opioid receptors
• Distribution: Peripherally restricted; avoids central nervous system-mediated side effects such as sedation and dysphoria

Primary Applications:

• In vivo and in vitro research into peripheral antinociception and visceral pain mechanisms
• Investigation of KOR-mediated peripheral anti-inflammatory pathways
• Differentiation of central versus peripheral opioid receptor pharmacology

For laboratory research use only. Not for human or veterinary clinical use.